Electrophysiologic Subtypes and Prognosis of Childhood Guillain-Barre Syndrome / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 91-99, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-208702
ABSTRACT
PURPOSE:
Guillain-Barre Syndrome(GBS) is an inflammatory polyneuropathy characterized by progressive, symmetric weakness and areflexia. GBS is currently subdivided into AIDP(acute inflammatory demyelinating polyneuropathy), AMAN(acute motor axonal neuropathy), AMSAN(acute motor sensory axonal neuropathy), and other subtypes based on results from electrophysiological studies. Our study is intended to evaluate the clinical characteristics and prognosis of pediatric GBS and its subtypes.METHODS:
From January 1999 to June 2009, We retrospectively reviewed of fifty patients with GBS the clinical manifestations and laboratory findings at the Asan Medical Center. Forty-six patients were classified into subtypes based on the results from electrophysiological studies.RESULTS:
Forty-five(90.0%) patients exhibited lower limb weakness, 26(56.5%) patients had both lower and upper limb weakness, and eleven(23.9%) had sensory nerve involvement seen at their initial presentation. Of the 46 patients, 22(47.8%) had AIDP, seven had AMAN(15.2%), 12 were unclassified(26.0%), and five had normal nerve conduction studies. The AIDP and AMAN groups were not significantly different in age, gender, and clinical characteristics. Five patients(22.7%) in the AIDP group and one patient(14.3%) in the AMAN group had respiratory failure, which did not differ significantly according to their group. However, the AMAN group needed a significantly longer period of time on average to walk independently than the AIDP group(99.2+/-97.0 days vs. 39.1+/-29.7 days, P=0.022).CONCLUSION:
Our electrophysiological data show that 15.2% of the pediatric patients with GBS had the AMAN-type disease, and these children underwent longer periods of recovery than children in the AIDP group.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polineuropatias
/
Prognóstico
/
Insuficiência Respiratória
/
Axônios
/
Amantadina
/
Estudos Retrospectivos
/
Síndrome de Guillain-Barré
/
Extremidade Inferior
/
Extremidade Superior
/
Condução Nervosa
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2010
Tipo de documento:
Artigo
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