Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
Blood Research
; : 187-192, 2016.
Article
em En
| WPRIM
| ID: wpr-209254
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: This study aimed to assess the treatment outcomes of ifosphamide, mesna, etoposide, and prednisolone (IMEP) combination regimen as a front-line chemotherapy in patients with peripheral T-cell lymphomas (PTCLs). METHODS: Clinical data of 38 newly diagnosed PTCLs patients who underwent IMEP at Busan Paik Hospital from January 2002 to December 2013 were retrospectively analyzed. RESULTS: The overall response rate was 68.5%, with 21 (55.3%) complete response/complete response unconfirmed and 6 (15.8%) partial response (PR). The median follow-up duration was 25.5 months (range, 0.2-87.3). The median overall survival was not reached and 2-year survival rate was 67%. The median progression free survival was 23 months. The most frequently reported adverse effects higher than grade 3 were hematologic toxicities including neutropenia (68.4%), thrombocytopenia (42.1%). There was no treatment-related mortality. CONCLUSION: IMEP regimen is effective and safe as a front-line chemotherapy in patients with PTCLs.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Trombocitopenia
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Prednisolona
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Taxa de Sobrevida
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Estudos Retrospectivos
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Seguimentos
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Mortalidade
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Linfoma de Células T Periférico
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Mesna
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Intervalo Livre de Doença
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Tratamento Farmacológico
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Blood Research
Ano de publicação:
2016
Tipo de documento:
Article