Phenobarbital dosage and blood level for control of neonatal seizure
Journal of the Korean Pediatric Society
;
: 1641-1646, 1993.
Artigo
em Coreano
| WPRIM
| ID: wpr-209935
ABSTRACT
Twenty-five neonates were observed for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone. Effective plasma concentration were 10.0~31.1microgram/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20microgram/ml, neonate required level above 30microgram/ml. We found that continued benefit was obtained until phenobarbital plasma concentrations reached 40microgram/ml and there was no adverse effects on cardiorespiratory function. We recommend that plasma phenobarbital concentrations should equal or surpass 40microgram/ml before additional anticonvulsants are used for neonates with seizure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenobarbital
/
Plasma
/
Convulsões
/
Anticonvulsivantes
Limite:
Humanos
/
Recém-Nascido
Idioma:
Coreano
Revista:
Journal of the Korean Pediatric Society
Ano de publicação:
1993
Tipo de documento:
Artigo
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