Polymeric Gene Delivery for Diabetic Treatment
Diabetes & Metabolism Journal
;
: 317-326, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-210390
ABSTRACT
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasmídeos
/
Polietilenoglicóis
/
Polilisina
/
Polímeros
/
DNA
/
RNA Mensageiro
/
Camundongos Endogâmicos NOD
/
Interleucina-10
/
Transplantes
/
RNA Interferente Pequeno
Limite:
Animais
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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