Histone lysine demethylases in mammalian embryonic development
Experimental & Molecular Medicine
;
: e325-2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-212097
ABSTRACT
Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas of epigenetics in the past decade. To date, with the exception of histone H3 lysine 79 methylation, the demethylases for all major lysine methylation sites have been discovered. These enzymes have been shown to be involved in various biological processes, with embryonic development being an exciting emerging area. This review will primarily discuss the involvement of these demethylases in the regulation of mammalian embryonic development, including their roles in embryonic stem cell pluripotency, primordial germ cell (PGC) formation and maternal-to-zygotic transition.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Acetilação
/
Fenômenos Biológicos
/
Cromatina
/
Histonas
/
Processamento de Proteína Pós-Traducional
/
Desenvolvimento Embrionário
/
Células-Tronco Embrionárias
/
Histona Desmetilases
/
Epigenômica
Limite:
Gravidez
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS