Assessment between Dopamine Receptor D2 (DRD2) Polymorphisms and Schizophrenia in Korean Population
Clinical Psychopharmacology and Neuroscience
;
: 88-93, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-21218
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of dopamine receptor D2 (DRD2) are associated with schizophrenia in Korean population.METHODS:
Four SNPs (rs4648317, rs7131056, rs4936270, and rs1076562) of DRD2 were selected and genotyped by direct sequencing in 197 schizophrenia patients and 370 control subjects. SNPAnalyzer, SNPStats, and Haploview version 4.2 programs were performed to analyze the genetic data. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, overdominant, and log-additive) were used to evaluate the odds ratios (ORs), 95% confidence intervals (CIs), and p values. For multiple testing, p values (pc) were re-evaluated by Bonferroni's correction.RESULTS:
The genotype frequency of DRD2 rs4936270 SNP was associated with the development of schizophrenia (p=0.0007, OR=1.71, 95% CI=1.16-2.52 in the codominant1 model; p=0.011, OR=1.63, 95% CI=1.12-2.37 in the dominant model; p=0.035, OR=1.41, 95% CI=1.03-1.95 in the log-additive model). The allele frequency of rs4936270 was also associated with the development of schizophrenia (p=0.024, OR=1.45, 95% CI=1.05-1.98). After Bonferroni's correction, the genotype distribution of rs4936270 was still related to the development of schizophrenia (pc=0.0028 in the codominant1 model; pc=0.044 in the dominant model). A linkage disequilibrium block consisted of rs4648317, rs7131056, and rs4936270. The CAT haplotype frequency was different between schizophrenia and controls (p=0.039).CONCLUSION:
These results suggest that DRD2 SNPs may be associated with the development of schizophrenia in Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
Haplótipos
/
Dopamina
/
Desequilíbrio de Ligação
/
Modelos Logísticos
/
Razão de Chances
/
Receptores Dopaminérgicos
/
Polimorfismo de Nucleotídeo Único
/
Frequência do Gene
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2012
Tipo de documento:
Artigo
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