The dose of cyclophosphamide for treating paraquat-induced rat lung injury
The Korean Journal of Internal Medicine
;
: 420-427, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-212582
ABSTRACT
BACKGROUND/AIMS:
Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury.METHODS:
Adult male Sprague-Dawley rats were allocated into five groups control, PQ (35 mg/kg, intraperitoneal injection), and PQ + CP (1.5, 15, or 30 mg/kg). The dimensions of lung lesions were determined using X-ray microtomography (micro-CT), and histological changes and cytokine levels were recorded.RESULTS:
The micro-CT results showed that 15 mg/kg CP was more effective than 1.5 mg/kg CP for treating PQ-induced lung injury. At a dose of 1.5 mg/kg, CP alleviated the histological evidence of inflammation and altered superoxide dismutase activity. Using 15 mg/kg CP reduced the elevated catalase activity and serum transforming growth factor (TGF)-beta1 level.CONCLUSIONS:
A CP dose of > 15 mg/kg is effective for reducing the severity of PQ-induced lung injury as determined by histological and micro-CT tissue examination, possibly by modulating antioxidant enzyme and TGF-beta1 levels.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paraquat
/
Edema Pulmonar
/
Superóxido Dismutase
/
Índice de Gravidade de Doença
/
Catalase
/
Citocinas
/
Ratos Sprague-Dawley
/
Estresse Oxidativo
/
Mediadores da Inflamação
/
Ciclofosfamida
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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