Two Cases of Refractory Adult-Onset Still's Disease Responding to Anakinra / 대한내과학회지
Korean Journal of Medicine
;
: 520-524, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-21294
ABSTRACT
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder with variable clinical features. The interleukin (IL)-1 receptor antagonist anakinra has been proposed as an alternative effective treatment in refractory AOSD. We report, for the first time in Korea, two cases of refractory AOSD in which anakinra treatment produced a clinical response. The first patient had frequent clinical flare-ups with fever, sore throat, myalgia, and pleuritic chest pain despite treatment with methotrexate and etanercept. In the second patient, treatments with various immunosuppressive agents failed to control the disease activity. Treatment with anakinra 100 mg/day was initiated in both cases. A complete clinical remission and improvement in the laboratory parameters were observed. The steroid dose was tapered without further clinical flare-ups. Anakinra appears to be an effective alternative treatment modality in patients with AOSD refractory to conventional disease-modifying anti-rheumatic drugs and corticosteroid therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor no Peito
/
Imunoglobulina G
/
Faringite
/
Metotrexato
/
Interleucinas
/
Doença de Still de Início Tardio
/
Receptores do Fator de Necrose Tumoral
/
Antirreumáticos
/
Proteína Antagonista do Receptor de Interleucina 1
/
Febre
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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