A case of Good's syndrome / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 142-147, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-213062
ABSTRACT
A 52-year-old woman suffering from recurrent orogenital ulcerations with superficial candidiasis and chronic mucocutaneous herpes simplex infection was admitted for headache and productive cough. She had undergone a thymectomy due to thymoma of an epithelial cell type several years ago. Radiologic and immunologic examinations revealed bronchiectasis in the left lower lobe, severe deficiency in all isotypes of immunoglobulin and an abnormal delayed hypersensitivity to ubiquitous antigens on skin test. Analysis of lymphocyte subsets in peripheral blood and bone marrow showed marked decreases in the proportion of cells bearing B cell markers. Her symptoms and signs were improved with antibiotics, antifungal and antiviral agents, and monthly administration of high dose intravenous immunoglobulin (IVIG, 400mg/kg). This is a rare case of Good's syndrome presenting, a humoral and cellular immune deficiency syndrome related with thymoma. The pathogenic mechanism of hypogammaglobulinemia in this case might be caused by a block in the early stage of B cell differentiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Timectomia
/
Timoma
/
Úlcera
/
Medula Óssea
/
Bronquiectasia
/
Candidíase
/
Imunoglobulinas
/
Testes Cutâneos
/
Diferenciação Celular
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
2002
Tipo de documento:
Artigo
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