Combined approaches using adverse outcome pathways and big data to find potential diseases associated with humidifier disinfectant
Environmental Health and Toxicology
;
: e2017003-2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-213139
ABSTRACT
According to previous survey, about two million of people were expected to suffer from toxic effects due to humidifier disinfectant (HD), regardless of healing or not. Extremely small group are recognized as HDs’ victims. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole because it is specific finding, compared with other diseases. To figure out overall effects from HDs, we recommend adverse outcome pathways (AOPs) as new approach. Reactive oxygen species (ROS) generation, decreased T-cell and pro-inflammatory cytokine release from macrophage could be key events between the exposure to HDs and diseases. ROS generation, decreased cell and pro-inflammatory cytokine release from macrophage could be cause of interstitial fibrosis, pneumonia and many other diseases such as asthma, allergic rhinitis, allergic dermatitis, fetal death, premature baby, autoimmune disease, hepatic toxicity, renal toxicity, cancer, and so on. We predict potential disease candidate by AOPs. We can validate the real risk of the adverse outcome by epidemiologic and toxicologic study using big data such as National Health Insurance data and AOPs knowledge base. Application of these kinds of new methods can find the potential disease list from the exposure to HD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumonia
/
Asma
/
Doenças Autoimunes
/
Fibrose
/
Linfócitos T
/
Espécies Reativas de Oxigênio
/
Dermatite
/
Bases de Conhecimento
/
Bronquíolos
/
Morte Fetal
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Environmental Health and Toxicology
Ano de publicação:
2017
Tipo de documento:
Artigo
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