Differences in risk for type 1 and type 2 ovarian cancer in a large cancer screening trial / 부인종양
Journal of Gynecologic Oncology
;
: e25-2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-213433
ABSTRACT
OBJECTIVE:
To investigate the role of previous gynecologic surgery, hormone use, and use of non-steroidal anti-inflammatory drugs on the risk of type 1 and type 2 ovarian cancer.METHODS:
We utilized data collected for the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. All diagnosed ovarian cancers were divided into three groups type 1, endometrioid, clear cell, mucinous, low grade serous, and low grade adenocarcinoma/not otherwise specified (NOS); type 2, high grade serous, undifferentiated, carcinosarcoma, and high grade adenocarcinoma/NOS; and other adenocarcinoma with grade or histology not specified, borderline tumors, granulosa cell tumors. The odds ratios for type 1, type 2, and other ovarian cancers were assessed with regard to historical information for specific risk factors.RESULTS:
Ibuprofen use was associated with a decrease in risk for type 1 ovarian cancer. Tubal ligation and oral contraceptive use were associated with a decrease in risk for type 2 ovarian cancer. A history of ectopic pregnancy was associated with a decreased risk for all ovarian cancers by almost 70%.CONCLUSION:
These findings support the hypothesis that carcinogenic pathways for type 1 and type 2 ovarian cancer are different and distinct. The marked reduction in all ovarian cancer risk noted with a history of ectopic pregnancy and salpingectomy implies that the fallopian tube plays a key role in carcinogenesis for both type 1 and type 2 ovarian cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Gravidez Ectópica
/
Procedimentos Cirúrgicos em Ginecologia
/
Anti-Inflamatórios não Esteroides
/
Ibuprofeno
/
Inquéritos e Questionários
/
Fatores de Risco
/
Anticoncepcionais Orais Hormonais
/
Detecção Precoce de Câncer
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Idoso
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2016
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS