ERG Immunohistochemistry and Clinicopathologic Characteristics in Korean Prostate Adenocarcinoma Patients
Korean Journal of Pathology
;
: 423-428, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-213501
ABSTRACT
BACKGROUND:
Transmembrane protease serine 2-ETS related gene (TMPRSS2-ERG) gene fusion, the most common genetic alternation in prostate cancer, is associated with protein expression of the oncogene ERG. Recently, an immunohistochemical staining method using an anti-ERG antibody was shown to have a strong correlation with altered ERG protein expression.METHODS:
We analyzed a total of 303 radical prostatectomy specimens (obtained from Korean prostate cancer cases) using a constructed tissue microarray and ERG immunohistochemical staining. Thereafter, we evaluated the association between ERG expression and clinicopathological factors.RESULTS:
The ERG-positive rate was 24.4% (74/303) and significantly higher ERG expression was observed in the subgroup with a lower Gleason score (p=0.004). Analysis of the histologic pattern of prostate adenocarcinomas revealed that tumors with discrete glandular units (Gleason pattern 3) displayed higher frequency of ERG expression (p=0.016). The ERG-positive rate was lower than that found (approximately 50%) in studies involving western populations. Other factors including age, tumor volume, initial protein-specific antigen level, a pathological stage and margin status were not significantly related with the ERG expression.CONCLUSIONS:
ERG immunohistochemical staining is significantly higher in tumors with well-formed glands and is associated with a lower Gleason score.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Próstata
/
Prostatectomia
/
Neoplasias da Próstata
/
Serina
/
Imuno-Histoquímica
/
Adenocarcinoma
/
Carga Tumoral
/
Fusão Gênica
/
Gradação de Tumores
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2012
Tipo de documento:
Artigo
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