Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
Experimental & Molecular Medicine
;
: e240-2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-213640
ABSTRACT
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipases
/
Retinaldeído
/
Vasos Sanguíneos
/
Células Endoteliais
/
Células Endoteliais da Veia Umbilical Humana
/
Hemorragia
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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