Correlation between Prognostic Factors and Lymph Node Metastases in Endometrial Cancer / 대한산부인과학회잡지

ABSTRACT

OBJECTIVE: To determine the valuable predictors of lymph nodes metastasis by analysing correlation with some prognostic factors in women with endometrial cancer. METHODS: A retrospective study was conducted in 49 women with endometrial cancer who underwent surgery with lymph node dissection or biopsy from 1988 to 2001 at our department. The prognostic factors analysed were age, obesity, histopathologic type and grade, depth of myometrial invasion, cervical invasion, adnexal metastasis, tumor size, hormone receptor, and preoperative CA-125. Univariate analysis was performed by x2 test and Fisher's exact test. RESULTS: Overall incidence of lymph node metastases was 28.6% (14/49). Lymph node metastases were statistically correlated with histopathologic type (P=0.048), depth of myometrial invasion (P=0.036), cervical invasion (P=0.001), and adnexal metastasis (P=0.015), however age, obesity, histopathologic grade, tumor diameter, estrogen and progesterone receptors, and preoperative CA125 were not statistically correlated. CONCLUSION: Histopathologic type, depth of myometrial invasion, cervical invasion, and adnexal metastasis were considered as predictors for lymph node metastases in endometrial cancer. Further studies for a large number of cases with multivariate analysis are needed.