Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth
Journal of the Korean Society of Neonatology
; : 49-58, 2011.
Article
em En
| WPRIM
| ID: wpr-213851
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM). METHODS: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data. RESULTS: Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity. CONCLUSION: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Peso ao Nascer
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Resistência à Insulina
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Fator de Crescimento Insulin-Like I
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Idade Gestacional
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Diabetes Gestacional
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Tamanho Corporal
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Desenvolvimento Fetal
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Adiponectina
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Sangue Fetal
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Teste de Tolerância a Glucose
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Journal of the Korean Society of Neonatology
Ano de publicação:
2011
Tipo de documento:
Article