Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
The Korean Journal of Internal Medicine
;
: 226-231, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-214109
ABSTRACT
BACKGROUND/AIMS:
We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness.METHODS:
We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The methacholine concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 0.05). No difference in BHR was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01 +/- 2.92 mg/mL vs. 17.38 +/- 0.61 mg/mL; p < 0.001).CONCLUSIONS:
These findings demonstrated that nasal eosinophilic inflammation might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Espirometria
/
Testes de Provocação Brônquica
/
Testes Intradérmicos
/
Rinite
/
Inquéritos e Questionários
/
Inquéritos Epidemiológicos
/
Fatores Etários
/
Hiper-Reatividade Brônquica
/
Distribuição por Idade
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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