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Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
The World Journal of Men's Health ; : 43-50, 2017.
Artigo em Inglês | WPRIM | ID: wpr-214130
ABSTRACT

PURPOSE:

This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS AND

METHODS:

Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.

RESULTS:

Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.

CONCLUSIONS:

Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Testículo / Testosterona / Fibrose / Ratos Sprague-Dawley / Guanosina Monofosfato / Estresse Oxidativo / Óxido Nítrico Sintase / Modelos Animais / Pressão Arterial Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: The World Journal of Men's Health Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Testículo / Testosterona / Fibrose / Ratos Sprague-Dawley / Guanosina Monofosfato / Estresse Oxidativo / Óxido Nítrico Sintase / Modelos Animais / Pressão Arterial Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: The World Journal of Men's Health Ano de publicação: 2017 Tipo de documento: Artigo