Lamotrigine and Lithium in the Treatment of Acute Bipolar Disorder / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 885-892, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-214229
ABSTRACT
BACKGROUND:
To evaluate the efficacy of lamotrigine on bipolar disorder, both manic and depressed episode, the author compared the effects of lamotrigine with lithium and placebo.METHOD:
Forty-seven manic patients with bipolar disorder and 43 depressed patients with bipolar disorder were treated with lamotrigine, lithium or placebo during 6 weeks. Their severity of symptoms were rated weekly using Young's Rating Scale for Mania and Hamilton Rating Scale for Depression.RESULTS:
In manic patients the therapeutic efficacy of lamotrigine was lower than that of lithium during baseline to week 2, but after week 3, lamotrigine was as effective as lithium. In depressed patients the therapeutic efficacy of lamotrigine was superior to lithium from week 2 to endpoint. Most patients tolerated well except that one patient developed skin rashes.CONCLUSION:
Lamotrigine seems to have antimanic and antidepressant effect as lithium in the treatment for acute bipolar disorder.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno Bipolar
/
Depressão
/
Exantema
/
Lítio
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2001
Tipo de documento:
Artigo
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