Age-Related CD26 Expression in Circulating T Cells in Peripheral Blood / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 174-180, 2005.
Article
em Ko
| WPRIM
| ID: wpr-214446
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Cytokine response changes with ageing. CD26 is known as an operational marker for Th1 pathway. In this study we investigated the possibility of CD26 as a practical marker for immunosenescence, Th1 or Th2 polarization. METHODS: We studied 99 subjects from 4 groups divided by age (thirties and sixties) and by hepatitis B. CD26 expression in T cells in peripheral blood was investigated by 3 color flow cytometry. Especially, CD26 expression in activated (HLA-DR+) T cells was compared among each group. RESULTS: CD26 expression in total T cells had the trend toward a decrease with ageing and decreased significantly especially in Ts cells (from 45.9+/-11.3% to 37.5+/-12.4%, P<0.05). Regardless of hepatitis B, CD26 expression in activated Th cells was not significantly different between the two age groups. HLA-DR expression in total T cells had the trend toward an increase in the elderly or hepatitis B and the dominant T cell subset responsible for this increase was Ts cell subset in the elderly and was Th cell subset in hepatitis B. CONCLUSIONS: We could not find the possibility of CD26 as a practical marker for immunosenescence reflecting Th1 polarization in activated Th cells. But CD26 or HLA-DR expression in total T cells had the trend to change with ageing and the change in Ts cells was more dominant than in Th cells.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Linfócitos T
/
Antígenos HLA-DR
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Citometria de Fluxo
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Hepatite B
Limite:
Aged
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Humans
Idioma:
Ko
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2005
Tipo de documento:
Article