Clinical applications of alpha2 adrenoceptor agonist
Anesthesia and Pain Medicine
; : 177-182, 2010.
Article
em Ko
| WPRIM
| ID: wpr-214626
Biblioteca responsável:
WPRO
ABSTRACT
alpha2 adrenoceptor agonists have been used successfully to treat patients with hypertension and patients withdrawing from long-term abuse of drugs or alcohol. alpha2 adrenoceptor agonists have also proved to be a clinically useful adjunct in clinical anesthetic practice as well as in chronic pain therapy because they have both anesthetic and analgesic-sparing activity. In addition, they have a role in providing hemodynamic stability in patients who are at risk of perioperative ischemia. Dexmedetomidine, a novel selective alpha2 adrenoceptor agonist, has been registered for use as a sedative-analgeic in a variety of clinical setting including monitored anesthesia care and intensive care unit. However, the side-effects of hypotension and bradycardia have limited the routine use of alpha2 adrenoceptor agonists perioporeatively. In this review, we discuss the pharmacology of alpha2 adrenoceptor agonists and their useful applications in anesthesia and intensive care unit.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Bradicardia
/
Dexmedetomidina
/
Dor Crônica
/
Hemodinâmica
/
Hipertensão
/
Hipotensão
/
Unidades de Terapia Intensiva
/
Isquemia
/
Anestesia
Limite:
Humans
Idioma:
Ko
Revista:
Anesthesia and Pain Medicine
Ano de publicação:
2010
Tipo de documento:
Article