Short Term Effect of Xalatan in Normal Koreans

ABSTRACT

Xalatan(Prostaglandin F-2alpha analog) is intraocular pressure reducing agent which increases uveoscleral outflow. It has little systemic side effect, has little effect on pupillary diameter prescribed a few times a day. As a result, it is an antiglaucoma drug convenient for usage. We observed the effect of intraocular pressure and side effect to investigate the clinical effectiveness of Xalatan in normal Koreans. We instilled Xalatan single dose a day to 10 subjects (20 eyes). We measured intraocular pressure by Goldman applanation tonometer on the first, the third, the fifth, the seventh, and the fourteenth day after dropping of the drug. Decreases in the intraocular pressure are statistically significant (p-value<0.05) compared to the pressure previous to the instillation. To evaluate the side effect of Xalatan, we investigated pupillary diameter, pulse rate, blood pressure, the change of iris color and performed external eye examination. However it didn`t show any side effect except for conjunctival injection. Therefore we expect that Xalatan will have a great effect on glaucoma patients in Korea.