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Study for the Antinociceptive Effect and Toxicity of Chronic Intrathecal Infusion of Cannabinoids in Rats / 대한통증학회지
The Korean Journal of Pain ; : 133-137, 2005.
Artigo em Coreano | WPRIM | ID: wpr-215227
ABSTRACT

BACKGROUND:

Cannabinoids have shown antinociceptive action. The aims of this study were to examine the effect of chronic infusion of a cannabinoids receptors agonist (WIN 55, 212-2) for thermal nociception at the spinal level, and to also observe the development of toxicity.

METHODS:

Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters with the nociceptive response (withdrawal response latency) determined by exposing the plantar surface of the hindpaw to radiant heat. Initially, the effect of intrathecal WIN 55, 212-2 was evaluated followed by the change in the effect at 1, 2, 3 and 4 weeks after repeated infusion. Finally, the histopathological findings were assessed 1 and 4 weeks following the infusion of WIN 55, 212-2.

RESULTS:

Intrathecal WIN 55, 212-2 was found to produce a limited antinociception during the thermal test. %MPE of WIN 55, 212-2 at 1, 2, 3, and 4 weeks after infusion was not different from each other. No abnormal pathological findings were observed following a chronic intrathecal infusion of WIN 55, 212-2.

CONCLUSIONS:

WIN 55, 212-2, a cannabinoids receptors agonist, may be useful in the management of thermal nociception, without changing the effectiveness or causing the toxicity following a chronic infusion at the spinal level.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Canabinoides / Ratos Sprague-Dawley / Catéteres / Nociceptividade / Temperatura Alta Limite: Animais / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Pain Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Canabinoides / Ratos Sprague-Dawley / Catéteres / Nociceptividade / Temperatura Alta Limite: Animais / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Pain Ano de publicação: 2005 Tipo de documento: Artigo