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New perspectives of biomarkers for the management of chronic hepatitis B
Clinical and Molecular Hepatology ; : 423-431, 2016.
Artigo em Inglês | WPRIM | ID: wpr-215525
ABSTRACT
With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: DNA Viral / Biomarcadores / Vírus da Hepatite B / Fatores de Risco / Hepatite B Crônica / Polimorfismo de Nucleotídeo Único / Transportadores de Ânions Orgânicos Dependentes de Sódio / Simportadores / Antígenos E da Hepatite B / Antígenos de Superfície da Hepatite B Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: DNA Viral / Biomarcadores / Vírus da Hepatite B / Fatores de Risco / Hepatite B Crônica / Polimorfismo de Nucleotídeo Único / Transportadores de Ânions Orgânicos Dependentes de Sódio / Simportadores / Antígenos E da Hepatite B / Antígenos de Superfície da Hepatite B Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Clinical and Molecular Hepatology Ano de publicação: 2016 Tipo de documento: Artigo