Minimal Phototoxic Dose for Vitiliginous Skin Lesions / 대한피부과학회지
Korean Journal of Dermatology
;
: 983-987, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-215728
ABSTRACT
BACKGROUND:
Photochemotherapy (PUVA) is the effective treatment for vitiligo. It is necessary to measure the minimal phototoxic dose (MPD) in order to ascertain a safe, effective UVA dose needed for irradiation during photochemotherapy.OBJECTIVE:
The purpose of this study was to standardize the MPD for vitiliginous lesions.METHOD:
The MPD was measured in 124 vitiligo patients. The number of patients monitored for topical and systemic MPD using the photosensitiser, 8-methoxypsoralen (8-MOP) were 41 and 83, respectively. MPD was also analysed according to sex, age, site of the vitiliginous lesions, duration of disease, season and administration route of the photosensitiser.RESULTS:
1. In the group assessed for topical application of 8-MOP cream, mean MPD was 0.62+/-0.59J/cm2. 2. In the group assessed for systemic administration of 8-MOP, mean MPD was 2.68+/-1.83J/cm2. 3. MPD in the group systemically administrated with 8-MOP was 4.32-fold to that of the topical application group (p<0.01). 4. In the case of both topical and systemic administration of the photosensitiser, 8-MOP, no significant differences in MPD were found due to the sex, age, site of vitiliginous lesions, duration of disease, or season in which MPD was administered to patients.CONCLUSION:
There was a significant difference in MPD between the topical application group and the systemic administration group.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fotoquimioterapia
/
Estações do Ano
/
Pele
/
Vitiligo
/
Metoxaleno
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS