A Rare Case of Transformation of Childhood Myelodysplastic Syndrome to Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
;
: 130-135, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-216010
ABSTRACT
Transformation of MDS into ALL during childhood is extremely rare. We report a rare case of an 8-yr-old girl who presented with refractory cytopenia of childhood (RCC) that transformed into ALL only 3 months after the diagnosis of childhood MDS. Although no cytogenetic abnormalities were observed in conventional karyotype and FISH analysis, we found several deletions on chromosomes 5q, 12q, 13q, and 22q. Partial homozygous deletion of the RB1 gene was observed on microarray analysis, with the bone marrow specimen diagnosed as ALL. This is the first case report of transformation of ALL from childhood MDS in Korea. We also compared the clinical, cytological, and cytogenetic features of 4 previously reported childhood MDS cases that transformed into ALL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndromes Mielodisplásicas
/
Células da Medula Óssea
/
Transformação Celular Neoplásica
/
Proteína do Retinoblastoma
/
Aberrações Cromossômicas
/
Hibridização in Situ Fluorescente
/
Deleção de Genes
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Cariotipagem
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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