The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
Gut and Liver
; : 641-648, 2015.
Article
em En
| WPRIM
| ID: wpr-216105
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS: Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA). RESULTS: A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p<0.0001). For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001). Compared with M2-PK ELISA, iM2-PK exhibited significantly enhanced sensitivity for CRC (97.5% vs 80.0%, p=0.0289). The sensitivity of iM2-PK was higher in advanced stages of CRC compared with cancers confined to the mucosa and submucosa (p<0.05). However, lymph node metastasis had no influence on the sensitivity of iM2-PK. CONCLUSIONS: The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT. Given its rapid results and convenience, CRC screening using iM2-PK is promising.
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Índice:
WPRIM
Assunto principal:
Lesões Pré-Cancerosas
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Piruvato Quinase
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Kit de Reagentes para Diagnóstico
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Ensaio de Imunoadsorção Enzimática
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Neoplasias Colorretais
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Biomarcadores Tumorais
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Adenoma
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Valor Preditivo dos Testes
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Cromatografia de Afinidade
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Sensibilidade e Especificidade
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adult
/
Aged
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Aged80
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Female
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Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2015
Tipo de documento:
Article