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A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study
Gut and Liver ; : 607-614, 2015.
Artigo em Inglês | WPRIM | ID: wpr-216110
ABSTRACT
BACKGROUND/

AIMS:

Proton pump inhibitors (PPIs) act by irreversibly binding to the H+-K+-ATPase of the proton pump in parietal cells and may possibly affect the vacuolar H+-ATPase in osteoclasts.

METHODS:

We investigated the effect of 8 weeks of PPI treatment on the parameters of bone turnover and compared PPI with revaprazan, which acts by reversibly binding to H+-K+-ATPase in proton pumps. This study was a parallel randomized controlled trial. For 8 weeks, either a PPI or revaprazan was randomly assigned to patients with gastric ulcers. The parameters of bone turnover were measured at the beginning of and after the 8-week treatment period.

RESULTS:

Twenty-six patients (PPI, n=13; revaprazan, n=13) completed the intention-to-treat analysis. After the 8-week treatment period, serum calcium and urine deoxypyridinoline (DPD) were increased in the PPI group (serum calcium, p=0.046; urine DPD, p=0.046) but not in the revaprazan group. According to multivariate linear regression analysis, age > or =60 years was an independent predictor for the changes in serum calcium and urine DPD.

CONCLUSIONS:

In elderly patients, administering a PPI for 8 weeks altered bone parameters. Our study suggested that PPIs might directly alter bone metabolism via the vacuolar H+-ATPase in osteoclasts.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoclastos / Pirimidinonas / Osso e Ossos / Modelos Lineares / Cálcio / Análise Multivariada / Estudos Prospectivos / Remodelação Óssea / Tetra-Hidroisoquinolinas / Inibidores da Bomba de Prótons Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional / Estudo prognóstico Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Gut and Liver Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoclastos / Pirimidinonas / Osso e Ossos / Modelos Lineares / Cálcio / Análise Multivariada / Estudos Prospectivos / Remodelação Óssea / Tetra-Hidroisoquinolinas / Inibidores da Bomba de Prótons Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional / Estudo prognóstico Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Gut and Liver Ano de publicação: 2015 Tipo de documento: Artigo