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Clinical Value of Cyclooxygenase-2 Expression in Human Breast Carcinoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 192-198, 2004.
Artigo em Inglês | WPRIM | ID: wpr-216206
ABSTRACT

PURPOSE:

To determine whether COX-2 expression is associated with clinicopathological parameters, including c-erb-B2 overexpression and angiogenesis, and the disease- free survival of patients with operable breast cancer. MATERIALS AND

METHODS:

Paraffin-embedded tissue samples were selected from 205 patients surgically resected for breast cancer, between 1991 and 1997, and followed- up for at least 4 years. Samples were immunohistochemically stained with antibodies to COX-2, c-erb-B2 and CD34.

RESULTS:

COX-2 and c-erb-B2 expressions were detected in 118/205 (57.6%) and 58/205 (28.3%) patients, respectively. COX-2 expression was significantly higher in c-erb-B2 positive than c-erb-B2 negative tumors (75.9% vs. 49.7%, p-value 0.001). COX-2 expression was positively correlated with microvessel count (13.3+/-8.0 vs. 6.6+/-7.0, p-value 0.050), but not with other clinicopathological characteristics, including tumor size, involved axil lary lymph nodes and estrogen or progesterone receptor status. Although COX-2 expression itself was not a prognostic marker, breast cancer patients with tumors that co-expressed both COX-2 and c-erb-B2 had a poorer 5-year disease-free survival rate than those that did not (60.2% vs. 78.3%, p-value 0.0527).

CONCLUSION:

Our data suggest that COX-2 expression occurs frequently in c-erb-B2 positive breast cancer, and co-expression of COX-2 and c-erb-B2 may be a useful prognostic marker in patients with operable breast cancer.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Mama / Neoplasias da Mama / Receptores de Progesterona / Intervalo Livre de Doença / Estrogênios / Ciclo-Oxigenase 2 / Microvasos / Linfonodos / Anticorpos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Mama / Neoplasias da Mama / Receptores de Progesterona / Intervalo Livre de Doença / Estrogênios / Ciclo-Oxigenase 2 / Microvasos / Linfonodos / Anticorpos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2004 Tipo de documento: Artigo