Antithrombin-III as an early prognostic factor in children with acute lung injury / 소아과
Korean Journal of Pediatrics
;
: 443-448, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-216260
ABSTRACT
PURPOSE:
To evaluate the potential prognostic value of the antithrombin-III (AT-III) level in the children with acute lung injury (ALI), we analyzed several early predictive factors of death including AT-III level at the onset of ALI and compared the relative risk of them for mortality.METHODS:
Over a 18-month period, a total of 198 children were admitted to our pediatric intensive care unit and 21 mechanically ventilated patients met ALI criteria, as defined by American-European consensus conference, i.e., bilateral pulmonary infiltrates and PaO2/FiO2 lower than 300 without left atrial hypertension. Demographic variables, hemodynamic and respiratory parameters, underlying diseases, as well as Pediatric Risk of Mortality-III (PRISM-III) scores and Lung Injury Score (LIS) at admission were collected. AT-III levels were measured within 3 hours after admission. These variables were compared between survivors and non-survivors and entered into a multiple logistic regression analysis to evaluate their independent prognostic roles.RESULTS:
The overall mortality rate was 38.1% (8/21). Non-survivors showed lower age, lower lung compliance, higher PEEP, higher oxygenation index (OI), lower arterial pH, lower PaO2/FiO2, higher PRISM-III score and LIS, and lower AT-III level. PRISM-III score, LIS, OI and decreased AT-III level (less than 70%) were independently associated with a risk of death and the odds ratio of decreased AT-III level for mortality is 2.75 (95% confidence interval; 1.28-4.12)CONCLUSION:
These results suggest that the decreased level of AT-III is an important prognostic factor in children with ALI and the replacement of AT-III may be considered as an early therapeutic trial.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Modelos Logísticos
/
Razão de Chances
/
Complacência Pulmonar
/
Mortalidade
/
Sobreviventes
/
Consenso
/
Lesão Pulmonar
/
Lesão Pulmonar Aguda
/
Hemodinâmica
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2007
Tipo de documento:
Artigo
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