Clinical Review of the Etiologic Factors in Patients with Aambiguous Genitalia / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1545-1551, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-216402
ABSTRACT
OBJECTIVE:
To review and evaluate the etiologic factors in patients with ambiguous genitaliaMETHODS:
We reviewed the medical records of the patients in whom ambiguous genitalia was identified in Asan Medical Center from Jan, 1989 to Dec, 2002. Patients with isolated cryptorchidism, isolated hypospadias, or congenital fatal anomalies involving multiple organs were excluded in our series.RESULTS:
A total of 58 cases were evaluated. The most common cause was congenital adrenal hyperplasia (CAH) (18 cases, 31.0%), followed by partial androgen insensitivity syndrome (AIS) (16 cases, 27.6%), true hermaphroditism (9 cases, 15.5%), and mixed gonadal dysgenesis (5 cases, 8.6%). Morphologic abnormalities observed in patients with ambiguous genitalia were hypospadias (52.5%), clitoromegaly (47.5%), palpable gonads (45.8%), bifid scrotum (23.7%), penoscrotal transposition (22%), cryptorchidism (18.6%), vaginal wall abnormality (10.2%), and M llerian remnant (3.4%). By karyotyping, 46XX, 46XY, and Y containing mosaicism were found in 24, 22, and 9 patients, respectively. All of the 18 patients with CAH were found to have 21-hydroxylase deficiency and all cases of androgen insensitivity syndrome were partial type.CONCLUSION:
These findings suggest that etiologic background might be different in patients with ambiguous genitalia in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Escroto
/
Transtornos do Desenvolvimento Sexual
/
Síndrome de Resistência a Andrógenos
/
Esteroide 21-Hidroxilase
/
Prontuários Médicos
/
Hiperplasia Suprarrenal Congênita
/
Criptorquidismo
/
Transtornos Ovotesticulares do Desenvolvimento Sexual
/
Genitália
/
Disgenesia Gonadal Mista
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2004
Tipo de documento:
Artigo
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