Effect of Platelet-rich Plasma(PRP) on Regeneration of Rat Sciatic Nerve in a Silicone Chamber
Journal of the Korean Society of Plastic and Reconstructive Surgeons
;
: 105-109, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-216549
ABSTRACT
PURPOSE:
The purpose of this study is to determine the effect of platelet-rich plasma(PRP) on rat sciatic nerve regeneration in a 10mm silicone chamber.METHODS:
A total of 6 inbred Lewis rats were used in this study. Bilateral sciatic neurectomy was performed on each rat. On one side, silicone chambers containing PRP solutions were implanted; on the contralateral side, the chambers without PRP were implanted as a control. In 12 weeks post-implantation, chambers were retrieved and both gastrocnemius muscles were excised. Nerves biopsy samples were examined under a light microscope after Masson trichrome staining.RESULTS:
Cross sections of the midpoints of PRP treated nerves were significantly larger and appeared more mature than those of controls.CONCLUSION:
Based on morphological evidence, PRP has a positive effect on neural regeneration, and it may therefore be useful for treating peripheral nerve injuries.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Endogâmicos Lew
/
Regeneração
/
Nervo Isquiático
/
Silicones
/
Biópsia
/
Plasma Rico em Plaquetas
/
Traumatismos dos Nervos Periféricos
/
Luz
/
Músculos
/
Regeneração Nervosa
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of the Korean Society of Plastic and Reconstructive Surgeons
Ano de publicação:
2010
Tipo de documento:
Artigo
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