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Clinical Analysis of Lymphocyte Population Changes in Severe Head Injured Patients Using Flow Cytometry
Journal of Korean Neurosurgical Society ; : 695-700, 1996.
Artigo em Coreano | WPRIM | ID: wpr-216783
ABSTRACT
Despite advancement in diagnosis and progress in the management of intracranial pressure, infection remains a common complication following severe head injury. This following study attempts to better define the cell mediated immunity that decreased immediately following severe head injury. Twenty-five patients admitted with severe head injury(mean Glasgow Coma Scale, 5.32) were studied at the emergency rooms. The control group consisted of 25 mildly head-injured patients requiring hospital observation. Phenotyping of peripheral blood lymphocytes(PBL), determined by flow cytometry using monoclonal antibodies to lymphocytes subpopulation and HLA-DR receptors, was performed immediately following head injury. When severely head-injured patients were compared with controls, it was observed that the total T-cell counts(p<0.01) were markedly decreased, whereas the NK cell counts(p<0.01) were found to be increased. Infection rate of the study group was 44% and the majority of infections occur within the first 10 days after sever head injury. The results of this study suggests that severely head-injured patients had a decreased T-cell population and subpopulation in lines with higher infection rate.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Linfócitos / Linfócitos T / Pressão Intracraniana / Antígenos HLA-DR / Escala de Coma de Glasgow / Diagnóstico / Serviço Hospitalar de Emergência / Citometria de Fluxo / Cabeça Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Journal of Korean Neurosurgical Society Ano de publicação: 1996 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Linfócitos / Linfócitos T / Pressão Intracraniana / Antígenos HLA-DR / Escala de Coma de Glasgow / Diagnóstico / Serviço Hospitalar de Emergência / Citometria de Fluxo / Cabeça Tipo de estudo: Estudo diagnóstico Limite: Humanos Idioma: Coreano Revista: Journal of Korean Neurosurgical Society Ano de publicação: 1996 Tipo de documento: Artigo