Etiopathology of Behcet's disease: herpes simplex virus infection and animal model
Yonsei Medical Journal
;
: 359-364, 1997.
Artigo
em Inglês
| WPRIM
| ID: wpr-217306
ABSTRACT
The etiology of Behcet's disease has been proposed as being a viral, bacterial, genetic and immunological disorder. After Hulusi Behcet's viral etiological hypothesis, many investigators have tried to confirm this. Scrapings and fluids from patients were applied to subculture in chorioallantoic membranes of fertilized eggs as well as in mice and rabbits by direct intracerebral injection. Since the 1980s, in situ hybridization, blotting, and polymerase chain reaction has also been applied to identify the herpes simplex virus DNA and RNA in patients. Animal models were developed based on environmental pollutants, bacterial and human heat shock protein derived peptides and virus injection. Using these animal models separately and/or concurrently, allows for a more effective investigation into Behcet's disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dados de Sequência Molecular
/
Síndrome de Behçet
/
Sequência de Aminoácidos
/
Modelos Animais de Doenças
/
Herpes Simples
/
Animais
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1997
Tipo de documento:
Artigo
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