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Clinical Manifestations of Norovirus Infection in Korean Pediatric Cancer Patients / 소아감염
Korean Journal of Pediatric Infectious Diseases ; : 40-47, 2011.
Artigo em Inglês | WPRIM | ID: wpr-217565
ABSTRACT

PURPOSE:

Norovirus infection, a common cause of community-acquired gastroenteritis, can also lead to severe illness in immunocompromised patients. We investigated clinical manifestations of norovirus infection in pediatric cancer patients.

METHODS:

Stool specimens were collected from pediatric patients with gastrointestinal symptoms between November 2008 and September 2009 at Samsung Medical Center, Seoul, Korea. Norovirus infection was identified by reverse-transcription polymerase chain reaction (RT-PCR). A retrospective chart review was performed in pediatric cancer patients who were diagnosed with norovirus infection.

RESULTS:

Ten patients were diagnosed with norovirus infection by RT-PCR in stool samples. The median age was 0.83 years (range 0.25-5.5 years) and the male to female ratio was 1.51 (6 males and 4 females). Underlying diseases were hematologic malignancies (4/10, 40%), neuroblastoma (4/10, 40%), and brain tumors (2/10, 20%). Three patients were infected before hematopoietic cell transplantation (HCT) and four patients after HCT. All patients had diarrhea (10/10, 100%), with a median frequency of diarrhea of 8.5 times/day (range 4-22 times/day). Median virus shedding duration was 72.5 days (range 19-299 days). Four patients with pneumatosis intestinalis were conservatively treated with bowel rest and total parenteral nutrition. One patient with severe diarrhea and bloody stool had concomitant chronic gut graft-versus-host disease (GVHD). Norovirus infection-related mortality was not observed.

CONCLUSION:

Norovirus infection can cause significant clinical manifestations with prolonged viral shedding in immunocom-promised patients. Norovirus should be considered in pediatric cancer patients with severe gastrointestinal symptoms.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Encefálicas / Reação em Cadeia da Polimerase / Estudos Retrospectivos / Hospedeiro Imunocomprometido / Nutrição Parenteral Total / Eliminação de Partículas Virais / Transplante de Células / Neoplasias Hematológicas / Transplantes / Norovirus Tipo de estudo: Estudo observacional Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Korean Journal of Pediatric Infectious Diseases Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Encefálicas / Reação em Cadeia da Polimerase / Estudos Retrospectivos / Hospedeiro Imunocomprometido / Nutrição Parenteral Total / Eliminação de Partículas Virais / Transplante de Células / Neoplasias Hematológicas / Transplantes / Norovirus Tipo de estudo: Estudo observacional Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Korean Journal of Pediatric Infectious Diseases Ano de publicação: 2011 Tipo de documento: Artigo