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Establishment of an HLA-matched Platelet Donor Registry for the Management of Patients with Platelet Refractoriness / 대한수혈학회지
Korean Journal of Blood Transfusion ; : 203-214, 1999.
Artigo em Coreano | WPRIM | ID: wpr-218059
ABSTRACT

BACKGROUND:

Heavily transfused patients commonly become refractory to platelet transfusion. Patients with platelet refractoriness due to HLA alloimmunization need HLA-matched platelet transfusion. We have established an hospital-based donor registry of HLA-typed platelet donors for the first time in Korea and evaluated the possibility of HLA-matched platelet supplies.

METHODS:

A total of 450 donors were registered and typed for HLA class I (A, B, C) antigens. A computer program was developed and used for the donor registry and HLA-matched donor search. A simulation study was performed on the availability of HLA-matched platelets for 100 patients from a pool of 450 donors. The availability of HLA-matched and cross reactive epitope group (CREG)-matched donors were analysed for HLA-A, B antigens. The CREGs defined by Fuller, Rodey, and UCLA criteria were used. RESLUTS Among 100 patients, 63% had HLA-identical or HLA-matched (match grade A, B1U, B2U) donors with only a low number of donors (mean 1.4) available per patient. Including CREG-matches (match grade B1X, B2UX, B2X), majority (98%) of the patients had HLA- or CREG-matched (match grade A~B2X) platelet donors with a higher number of donors (mean 26.6~40.5 by different CREG criteria) available per patient. Majority (86-98%) of the patients had 20 or more A~B4X matched donors, and about two thirds (61-74%) of the patients had 20 or more A~B2X matched donors. However, the number of ABO-identical matched donors was less than 30% of the total HLA- or CREG-matched donors.

CONCLUSION:

We established an HLA-matched platelet donor registry and using a donor pool size of < 500 donors, attainable in an hospital-based donor registry, the possibility of HLA-matched platelet supplies was confirmed in this study. However, for more satisfactory and ABO-matched platelet supplies a larger pool size is needed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doadores de Tecidos / Plaquetas / Antígenos HLA-A / Transfusão de Plaquetas / Equipamentos e Provisões / Coreia (Geográfico) Limite: Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Blood Transfusion Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doadores de Tecidos / Plaquetas / Antígenos HLA-A / Transfusão de Plaquetas / Equipamentos e Provisões / Coreia (Geográfico) Limite: Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Blood Transfusion Ano de publicação: 1999 Tipo de documento: Artigo