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A comparison of the relaxation responses of isolated cavernosal smooth muscles by endothelium-independent and endothelium-dependent vasodilators in diabetic men with impotenc
Journal of Korean Medical Science ; : 1-6, 1995.
Artigo em Inglês | WPRIM | ID: wpr-218196
ABSTRACT
This study was intended to explore the effects of endothelium-independent, direct smooth muscle relaxants(papaverine, verapamil) and endothelium-dependent vasodilators(acetylcholine, bradykinin, adenosine) on the isolated cavernosal smooth muscle strips taken from diabetic men with impotence. When smooth muscle contraction was evoked with norepinephrine for the study of relaxation to these vasodilators, the tension induced was similar in diabetic and non-diabetic men with importance. Papaverine showed the strongest relaxation response followed by verapamil, acetylcholine, bradykinin and adenosine both in non-diabetic and in diabetic men. Relaxation of the cavernosal tissues to endothelium-independent vasodilators was similar in non-diabetic and diabetic men. However, the relaxation response of the tissues to endothelium-dependent vasodilators was significantly reduced in the diabetic group compared with that in the non-diabetic group (p<0.05). In conclusion, the impairment of endothelium-mediated relaxation of cavernosal smooth muscle seems to play a more important role in the pathogenesis of diabetogenic impotence rather than the problem of smooth muscle itself. This finding forms a rational basis for the use of intracavernosal injections of vasodilators to induce endothelium-independent relaxation of the cavernosal smooth muscle in the patients with diabetogenic impotence.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pênis / Vasodilatadores / Técnicas In Vitro / Estudo Comparativo / Endotélio Vascular / Diabetes Mellitus / Disfunção Erétil / Pessoa de Meia-Idade / Relaxamento Muscular / Músculo Liso Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 1995 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pênis / Vasodilatadores / Técnicas In Vitro / Estudo Comparativo / Endotélio Vascular / Diabetes Mellitus / Disfunção Erétil / Pessoa de Meia-Idade / Relaxamento Muscular / Músculo Liso Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 1995 Tipo de documento: Artigo