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Histological Comparison of Vascular Grafts in a Pig to Goat Xenotransplantation Model / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery ; : 427-433, 2006.
Artigo em Coreano | WPRIM | ID: wpr-218360
ABSTRACT

BACKGROUND:

Current vascular prostheses are considered still inadequate for reconstruction of small-diameter vessels. To evaluate the potential use of xenograft vessels as small diameter arterial grafts, we implanted porcine vessels in goats. The grafts were treated with two different processes, freezing and acellularization, before implantation, and gross inspection as well as microscopic examination followed after a predetermined period. MATERIAL AND

METHOD:

Bilateral porcine carotid arteries were harvested and immediately stored at -70 degrees C within tissue preservation solution. One of them was designated as frozen xenograft vessel. The other one was put on acellularization process using NaCl-SDS solution and stored frozen until further use. Grafts were implanted in the place of carotid arteries of the same goat. The grafts have remained implanted for 1, 3, and 6 months in three animals, respectively. Periodic ultrasonographic examinations were performed during the observation period. After explantation, the grafts were analyzed grossly and histologically under light microscope.

RESULT:

All animals survived the experimental procedure without problems. Ultrasonographic examinations showed excellent patency of all the grafts during the observation period. Gross examination revealed nonthrombotic, patent lumens with smooth surfaces. Microscopic examinations of the explanted grafts showed cellular reconstruction at the 6-month stage in both grafts. Although more inflammatory responses were observed in the early phase of frozen xenografts, there was no evidence of significant rejection.

CONCLUSION:

These findings suggest that porcine xenograft vessels, regardless of pre-implantation processes of acelluarization or freezing, can be acceptably implanted in goats, although short duration of observation in a small number of animals may limit this study.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Preservação de Tecido / Transplante Heterólogo / Bioprótese / Prótese Vascular / Cabras / Artérias Carótidas / Transplantes / Xenoenxertos / Congelamento Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Preservação de Tecido / Transplante Heterólogo / Bioprótese / Prótese Vascular / Cabras / Artérias Carótidas / Transplantes / Xenoenxertos / Congelamento Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: The Korean Journal of Thoracic and Cardiovascular Surgery Ano de publicação: 2006 Tipo de documento: Artigo