Outcomes of Palliative Weekly Low-Dose Gemcitabine-Cisplatin Chemotherapy in Anthracycline- and Taxane- Pretreated Metastatic Breast Cancer Patients / 한국유방암학회지
Journal of Breast Cancer
;
: 339-343, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-218644
ABSTRACT
PURPOSE:
The combination of gemcitabine and cisplatin (GP) has been shown to be safe and efficacious for patients with metastatic breast cancer (MBC), pretreated with anthracyclines and taxanes. We assessed the efficacy and safety of weekly low-dose GP in patients with MBC.METHODS:
We collected clinicopathological data from MBC patients who had been treated with gemcitabine, 800 mg/m2 plus cisplatin, 30 mg/m2 intravenously, on days 1 and 8 every 3 weeks, between January 2001 and November 2011 in Korea.RESULTS:
The analysis included 294 patients previously treated anthracycline-xand taxane-based chemotherapies prior to GP (median age, 48 years [range, 28-78 years]; median follow-up duration, 63.9 months). Seventeen patients (5.8%) discontinued GP because of toxicities. The median progression-free survival (PFS) was 3.9 months (95% confidence interval [CI], 3.394.4 months) and the median overall survival (OS) was 27.7 months (95% CI, 17.6-37.8 months) months. Statistically significant factors for PFS were performance status (Eastern Cooperative Oncology Group, > or =2 vs. 2 years; HR, 1.66; 95% CI, 1.28-1.95, p1 year; HR, 1.48; 95% CI, 1.13-1.95, p2 years; HR, 2.07; 95% CI, 1.36-3.14; p<0.001) and the presence of brain metastasis (HR, 2.14; 95% CI, 1.27-3.61; p=0.004) were important factors for OS after GP treatment.CONCLUSION:
Weekly low-dose GP chemotherapy appears safe and effective for heavily pretreated MBC patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Neoplasias da Mama
/
Seguimentos
/
Cisplatino
/
Intervalo Livre de Doença
/
Antraciclinas
/
Taxoides
/
Diagnóstico
/
Tratamento Farmacológico
/
Coreia (Geográfico)
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Breast Cancer
Ano de publicação:
2014
Tipo de documento:
Artigo
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