Your browser doesn't support javascript.
loading
Intratumoral Injection of Holmium-Chitosan Complex in Prostate Cancer / 대한비뇨기과학회지
Korean Journal of Urology ; : 229-235, 2004.
Artigo em Coreano | WPRIM | ID: wpr-218701
ABSTRACT

PURPOSE:

The aim of this study was to pathologically evaluate the therapeutic and toxic effects of the 166Ho-chitosan complex(166HC) on prostatic cancer. MATERIALS AND

METHODS:

The DU-145 cell line was subcutaneously heterotransplanted into 30 nude mice, resulting in 24 prostatic cancers. The 24 nude mice with prostatic cancer were divided into four groups. Group I(n=6) received 0.5ml normal saline, group II(n=6) 0.5ml chitosan, group III(n=6) 370 MBq of 166HC and group IV(n=6) 740 MBq of 166HC per 1cm3, intratumorally. The tumor sizes were measured at 1 and 2 weeks after injection. The 24 mice were sacrificed and pathological examination performed Haematoxylin & Eosin(H & E) staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling(TUNEL) staining.

RESULTS:

Two weeks after injection of 166HC, the tumor volumes in groups III and IV were smaller than those in groups I and II(p<0.05). H & E staining of the tumors showed wide central necrosis in groups III and IV, but not in groups I and II. TUNEL staining showed false positive reactions along the peripheral margins in all groups. No toxic changes were found in the liver, kidney, peripheral blood and bone marrow.

CONCLUSIONS:

An intratumoral injection of 166HC appears to be a new, safe and promising alternative radiotherapeutic modality for the local control of prostatic cancer, with minimized toxicities as the administered 166HC is retained at the injection site.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Neoplasias da Próstata / Medula Óssea / Linhagem Celular / Marcação In Situ das Extremidades Cortadas / Quitosana / Desoxiuridina / Reações Falso-Positivas / Hólmio / Rim Limite: Animais Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Próstata / Neoplasias da Próstata / Medula Óssea / Linhagem Celular / Marcação In Situ das Extremidades Cortadas / Quitosana / Desoxiuridina / Reações Falso-Positivas / Hólmio / Rim Limite: Animais Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2004 Tipo de documento: Artigo