Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
Experimental & Molecular Medicine
;
: 52-58, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-219393
ABSTRACT
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha Rutin also lowers NF-kappaB activation in response to RANKL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Rutina
/
NF-kappa B
/
Fator de Necrose Tumoral alfa
/
Espécies Reativas de Oxigênio
/
Ligante RANK
/
Camundongos Endogâmicos C57BL
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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