Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats / 대한수의학회지
Korean Journal of Veterinary Research
;
: 245-252, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-219582
ABSTRACT
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-alpha and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Baço
/
Veias
/
Peso Corporal
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Ratos Sprague-Dawley
/
Diagnóstico
/
Nanopartículas
/
Indicadores e Reagentes
/
Injeções Intravenosas
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2014
Tipo de documento:
Artigo
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