Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis
The Korean Journal of Parasitology
;
: 239-243, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-219735
ABSTRACT
Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testes Cutâneos
/
Alérgenos
/
Curva ROC
/
Baratas
/
Proteínas de Insetos
/
Dermatophagoides farinae
/
Dermatophagoides pteronyssinus
/
Antígenos de Dermatophagoides
/
Hipersensibilidade
/
Medições Luminescentes
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2007
Tipo de documento:
Artigo
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