Role of murine Peyer's patch lymphocytes against primary and challenge infections with Cryptosporidium parvum
The Korean Journal of Parasitology
;
: 175-180, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-219745
ABSTRACT
In order to determine the role of Peyer's patch lymphocytes (PPL) in self-clearing of Cryptosporidium parvum infection in murine models, changes in PPL subsets, their cytokine expression, and in vitro IgG1 and IgA secretions by PPL were observed in primary- and challenge-infected C57BL/6 mice. In primary-infected mice, the percentages of CD4+ T cells, CD8+ T cells, sIgA+ B cells, IL-2+ T cells, and IFN-gamma+ T cells among the PPL, increased significantly (P 0.05) than those in primaryinfected mice. The results suggest that murine PPL play an important role in self-clearing of primary C. parvum infections through proliferation of CD4+, CD8+, IL-2+, and IFN-gamma+ T cells, and IgG1 and IgA-secreting B cells. In challenge infections, the role of T cells is reduced whereas that of B cells secreting IgA appeared to be continuously important.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Nódulos Linfáticos Agregados
/
Imunoglobulina A
/
Imunoglobulina G
/
Anticorpos Antiprotozoários
/
Linfócitos
/
Interferon gama
/
Interleucina-2
/
Cryptosporidium parvum
/
Organismos Livres de Patógenos Específicos
/
Criptosporidiose
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2007
Tipo de documento:
Artigo
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