Seizure and Thyroid Dysfunction Associated with High Dose of Quetiapine: Case Report / 신경정신의학

ABSTRACT

We report a case of seizure and thyroid dysfunction in a patient receiving quetiapine. A 31-year-old Korean woman with bipolar I disorder was observed to have a seizure attack after reduction of quetiapine from 1,200 mg/day to 1,000 mg/day and discontinuance of clonazepam 1 mg/day. Her thyroid function test also showed hyperthyroidism after quetiapine use. She had no known risk factors of seizure, and no known history of lithium ingestion. The patient was taking high dose quetiapine due to her manic symptoms. Using high dose of quetiapine may have resulted in a seizure attack in our patient with bipolar I disorder. Also, in this patient, quetiapine was probably associated with hyperthyroidism. It is not common that seizure occur with atypical antipsychotics, such as quetiapine, except clozapine, but special attention is required using high dose of atypical antipsychotics.