Understanding the Pathogenesis of Zika Virus Infection Using Animal Models
Immune Network
;
: 287-297, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-220082
ABSTRACT
Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polinésia
/
Biologia
/
Brasil
/
América Central
/
Saúde Pública
/
Incidência
/
Sistema Nervoso Periférico
/
Flaviviridae
/
Síndrome de Guillain-Barré
/
Modelos Animais
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Gravidez
País/Região como assunto:
América Central
/
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2017
Tipo de documento:
Artigo
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