Changes in Expressions of Endothelin-1, Microphthalmia Associated Transcription Factor, and Protease-activated Receptor-2 after Ultraviolet Irradiation / 대한피부과학회지
Korean Journal of Dermatology
;
: 1419-1424, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-220124
ABSTRACT
BACKGROUND:
A number of cytokines, growth factors and inflammatory mediators made by keratinocytes, fibroblasts and potentially other cells in the skin were shown to augment melanin production and/or melanin transfer to keratinocytes. A lot of studies were done to investigate the mechanisms. But there was no studies about sequential relationship between the suggestive factors. OBJECT To measure the changes in expressions of ET-1, MITF, and PAR-2 after UV exposure on skin in Korean. MATERIAL ANDMETHOD:
We established an immunohistochemical staining protocol for specimens which were obtained from UV-irradiated skin in four healthy Korean males on the 2nd, 4th, 7th days after UV irradiation.RESULT:
This study reveals the sequential relationship between ET-1, MITF, and PAR-2. ET-1 was increased at day 2 and decreased at day 4 and 7. MITF increased gradually day 2, day 4, and day 7. PAR-2 increased at day 4 and increased once more at day 7.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Queratinócitos
/
Microftalmia
/
Citocinas
/
Endotelina-1
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Fator de Transcrição Associado à Microftalmia
/
Fibroblastos
/
Melaninas
/
Melanócitos
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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