Amikacin therapy for urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli
The Korean Journal of Internal Medicine
;
: 156-161, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-220491
ABSTRACT
BACKGROUND/AIMS:
The number of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin outpatient parenteral antibiotic therapy (OPAT) for UTIs caused by ESBL-EC in patients not pre-treated with carbapenem.METHODS:
We retrospectively evaluated the outcomes of amikacin OPAT for UTIs caused by ESBL-EC.RESULTS:
From November 2011 to October 2012, eight females, who could not be hospitalized for carbapenem treatment, were treated with amikacin OPAT for nine episodes of non-bacteremic ESBL-EC UTIs. Seven of the eight patients had one or more comorbidities. Of the nine UTI cases, three had symptomatic lower UTIs and six had non-bacteremic upper UTIs. In all of the cases, symptomatic and laboratory improvements were observed following amikacin OPAT. One patient showed a delayed relapse with bilateral microabscesses 3 weeks after treatment cessation; however, a clinical and microbiological cure was eventually reached. All of the patients were able to tolerate amikacin OPAT without any significant nephrotoxicity or ototoxicity.CONCLUSIONS:
Amikacin OPAT represents a feasible therapeutic option for non-bacteremic UTIs caused by ESBL-EC in settings with limited resources.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Fatores de Tempo
/
Infecções Urinárias
/
Urina
/
Beta-Lactamases
/
Indução de Remissão
/
Esquema de Medicação
/
Amicacina
/
Testes de Sensibilidade Microbiana
/
Estudos Retrospectivos
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Idoso
/
Aged80
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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