Acute Lymphoblastic Leukemia with Chromosomal Translocation t (5; 14) (q31; q32) and Hypereosinophilia in a Child / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
;
: 108-113, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-220862
ABSTRACT
Hypereosinophilia has been associated with a variety of underlying disorders such as parasitic, fungal and mycobacterial infections, allergic disorders, collagen vascular diseases, or hypereosinophilic syndrome (HES). The association of acute lymphoblastic leukemia (ALL) and symptomatic eosinophilia is rare and only a few cases have been reported. HES probably occurs in less than 1% of all patients with ALL. The chromosomal translocation t (5; 14) (q31; q32) was cloned at the molecular level in ALL with eosinophilia. This translocation joined the immunoglobulin heavy chain region to the promoter region of the interleukin-3 (IL-3) gene in opposite transcriptional orientation. The IL-3 gene translocated with the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia. We describe a 8-year-old boy who presented with hypereosinophilia and concurrent ALL with t (5; 14).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Translocação Genética
/
Doenças Vasculares
/
Leucemia
/
Colágeno
/
Regiões Promotoras Genéticas
/
Interleucina-3
/
Células Clonais
/
Cadeias Pesadas de Imunoglobulinas
/
Síndrome Hipereosinofílica
/
Eosinofilia
Limite:
Criança
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Pediatric Hematology-Oncology
Ano de publicação:
2005
Tipo de documento:
Artigo
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