Four Cases of Myelodysplastic Syndrome with Systemic Lupus Erythematosus / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 295-298, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-221294
ABSTRACT
Systemic lupus erythematosus (SLE) has been a well-known systemic autoimmune disease with hematologic abnormalities such as anemia, leukopenia, and thrombocytopenia. Myelodysplastic syndrome (MDS) is defined as a clonal expansion of BM derived pluripotent stem cells. Although SLE and MDS are independent disease entities, there have been several reports regarding rheumatic manifestations of MDS, which suggest that there might be a relationship between these two diseases in the pathogenetic sequence. We reviewed our cases of MDS and SLE and encountered four patients with both MDS and SLE, both of which developed concurrently. They were all women from 15 to 50 years old. They had anemia or pancytopenia. Bone marrow findings were disclosed as MDS, RA or hypoplastic MDS, RA. They had positive ANA at a titer above 1160 of homogeneous, speckled, or dense cytoplasmic pattern. Double-stranded DNA levels increased in all cases, whereas serum complement and immunoglobulin levels were decreased except in case 1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pancitopenia
/
Doenças Autoimunes
/
Células-Tronco
/
Trombocitopenia
/
Medula Óssea
/
Síndromes Mielodisplásicas
/
Proteínas do Sistema Complemento
/
DNA
/
Imunoglobulinas
/
Citoplasma
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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