Changing Trends of Serum Pepsinogen I/II Ratio in Asymptomatic Subjects
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 96-102, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-221405
ABSTRACT
BACKGROUND/AIMS:
Gastric atrophy can be diagnosed by serum pesinogen I/II ratio. The aim of this study was to investigate whether the changes of serum pepsinogen I/II ratio can be predicted by gastroscopy. MATERIALS ANDMETHODS:
Sixty healthy subjects who underwent screening for serum pepsinogen I/II levels, serum Helicobacter pylori (H. pylori) antibody, and gastroscopy for two sequential years were included. Endoscopic findings were classified into four different categories according to the degree of chronic atrophic gastritis; none, mild, moderate, and severe. Changes of the serum pepsinogen I/II ratio, body mass index, H. pylori antibody, and endoscopic findings were analyzed after a year.RESULTS:
The serum pepsinogen I/II ratio showed a tendency to decrease after a year in subjects with H. pylori infection (P=0.013) and those with moderate to severe atrophic gastritis (P=0.004), whereas it increased in subjects without H. pylori infection and those with none to mild atrophic gastritis. On multivariate analysis, the degree of atrophic gastritis was the only factor that was related to the changing trends of the serum pepsinogen I/II ratio (odds ratio=5.385, P=0.023).CONCLUSIONS:
The degree of atrophic gastritis on endoscopic findings can predict the changes of the serum pepsinogen I/II ratio after a year. Regardless of the current status of H. pylori infection, the serum pepsinogen I/II ratio decreases after a year in subjects with moderate to severe atrophic gastritis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Atrofia
/
Índice de Massa Corporal
/
Programas de Rastreamento
/
Análise Multivariada
/
Helicobacter pylori
/
Gastroscopia
/
Pepsinogênio A
/
Gastrite Atrófica
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Ano de publicação:
2012
Tipo de documento:
Artigo
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